文章题目:Noveltreatmentstrategiesinrheumatoidarthritis
研究人员：BurmesterGR,et,al
期刊名称：TheLancet
发表时间：Jun10
影响因子：60.34
[1]核心亮点
1.Newtreatmentstrategieshavesubstantiallychangedthecourseofrheumatoidarthritis.新的治疗策略大大改变了类风湿关节炎的病程。
2.Rapiddiagnosisandatreat-to-targetapproachwithtightmonitoringandcontrol,canincreasethelikelihoodofremissioninpatientswithrheumatoidarthritis.对类风湿性关节炎患者进行快速诊断和靶向治疗，并严格监控，可增加患者病情缓解的可能性。
[2]思路与方法
本文按照治疗建议风湿性关节炎的最新治疗进展和预防类风湿性关节炎。在治疗建议中提到其中的治疗策略和TNF抑制剂的早期或者已建立类风湿性关节炎的相关内容。治疗新进展报告了生物类似物对于治疗的作用。
[3]摘要
Untilthes,thediagnosisofrheumatoidarthritishaddevastatingconsequences,whichusuallyledtoprogressivejointdestruction,reducedlifeexpectancy,earlyunemployment,andconsiderabledisability.Treatmentincludedthepyramidapproach,whichstartedwithbedrest,non-steroidalanti-inflammatorydrugs,andtheadditionofeffectivedisease-modifyingantirheumaticdrug(DMARD)therapyfollowingdiseaseprogression.ThefirstpaperinthisSeries,outlinedthepathophysiologyofrheumatoidarthritislearnedfromuseofbiologicsandsmallmoleculeinhibitorsinrheumatoidarthritis,andthispaperwillfocusonnoveltreatmentconceptsthatsubstantiallyalterthediseasecourseofthecondition,includingtreatmentofearlydiseasewithclassicDMARDmedicationoftenin
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